Daxxify lasts 6–9 months. Botox lasts 3–4 months. Both are FDA-approved botulinum toxin type A neurotoxins that smooth wrinkles. Daxxify uses a novel peptide stabilizer instead of human albumin, which is why it lasts longer. The results look identical — the only meaningful difference is how often you need to come back.
What Is Daxxify?
Daxxify (daxibotulinumtoxinA-lanm) is the newest FDA-approved neurotoxin, approved in September 2022 by Revance Therapeutics. It's the first truly new neurotoxin to enter the U.S. market in over a decade — and it's the only one that uses a proprietary stabilizing peptide instead of human serum albumin.
That one difference in formulation is why Daxxify lasts almost twice as long as Botox.
Botox (onabotulinumtoxinA) has been FDA-approved since 2002 and remains the most studied and trusted neurotoxin in the world. Over 8 million Botox treatments are performed annually in the U.S. alone.
How Long Does Each Last?
Most patients return every 3–4 months for maintenance. Some fast metabolizers may notice it fading at 10–12 weeks.
Clinical trials: 50% of patients maintained results at 6 months; 24% at 9 months. Most Daxxify patients come in just 1–2 times per year.
In Revance's FDA approval trials (the SAKURA 1 & 2 studies), Daxxify showed a median duration of 24 weeks — six months — for glabellar lines. Botox's clinical studies show a median duration of 16–18 weeks for the same area.
For patients who find Botox wearing off at 10 weeks or who simply hate scheduling quarterly appointments, Daxxify is a significant quality-of-life upgrade.
How They Work (And Why Daxxify Lasts Longer)
Both Botox and Daxxify are botulinum toxin type A neurotoxins. They work by temporarily blocking acetylcholine release at the neuromuscular junction — the signal that tells your facial muscles to contract. When the muscle can't contract, the overlying skin stays smooth.
The key difference is the stabilizing molecule:
- Botox uses human serum albumin to stabilize the toxin molecule.
- Daxxify uses a proprietary synthetic stabilizing peptide instead of human albumin. This peptide binds more tightly to the toxin, slowing its breakdown and extending how long it stays active in the tissue — the main reason Daxxify lasts longer.
Daxxify is also the first neurotoxin formulated without human albumin, which matters to some patients who prefer a product that doesn't use human blood-derived components.
Daxxify vs Botox: Side-by-Side
| Feature | Botox® | Daxxify® |
|---|---|---|
| Generic name | OnabotulinumtoxinA | DaxibotulinumtoxinA-lanm |
| Manufacturer | AbbVie (Allergan) | Revance Therapeutics |
| FDA approved | 2002 | 2022 |
| Stabilizer | Human serum albumin | Synthetic peptide |
| Duration | 3–4 months | 6–9 months ✓ |
| Treatments/year | 3–4 sessions | 1–2 sessions ✓ |
| Approved areas | Forehead, glabella, crow's feet + more | Glabellar lines (FDA); used off-label for other areas |
| Results look | Natural, softened | Natural, softened (identical) |
| Onset | 3–5 days | 3–5 days |
| Human albumin | Yes | No ✓ |
| Clinical track record | 20+ years | 2022–present |
Daxxify vs Botox vs Dysport vs Xeomin vs Jeuveau
Botox and Daxxify aren't the only neurotoxins on the market. There are five FDA-approved botulinum toxin type A products in the U.S., and they all work the same fundamental way — relaxing the muscles that cause expression lines. The differences come down to how long they last, how they're dosed, and a few formulation details. Here's how the full field compares:
| Neurotoxin | Generic name | Typical duration | What sets it apart |
|---|---|---|---|
| Botox® | OnabotulinumtoxinA | 3–4 months | The gold standard — 20+ years of data, most studied, baseline for unit dosing. |
| Daxxify® | DaxibotulinumtoxinA-lanm | 6–9 months ✓ | Longest-lasting; peptide stabilizer instead of human albumin. |
| Dysport® | AbobotulinumtoxinA | 3–4 months | Spreads a bit more (can suit larger areas like the forehead); dosed in different units — roughly 2.5–3 Dysport units ≈ 1 Botox unit. |
| Xeomin® | IncobotulinumtoxinA | 3–4 months | A "naked" toxin with no complexing proteins; roughly 1:1 with Botox. |
| Jeuveau® | PrabotulinumtoxinA-xvfs | 3–4 months | "Newtox" — approved for cosmetic frown lines only; roughly 1:1 with Botox. |
A few honest takeaways from this comparison:
- What lasts longer, Botox or Dysport? About the same — both run 3–4 months. Daxxify is the only one that lasts meaningfully longer (6–9 months).
- How many units of Dysport vs Botox? They're not interchangeable 1:1. It takes roughly 2.5–3 units of Dysport to equal 1 unit of Botox, which is why Dysport's per-unit price looks lower while the total cost of a treatment often lands in a similar range.
- Is Dysport cheaper than Botox? Per unit, yes — but because you need more units, the bottom-line cost per treatment is usually comparable.
- Xeomin and Jeuveau behave very much like Botox on duration; Xeomin's draw is its filtered, protein-free formula and Jeuveau's is competitive cosmetic pricing.
At Solas Health & Wellness, we focus on the two products we believe deliver the best results and value for our patients: Botox, the proven gold standard, and Daxxify, the longest-lasting option. If you're weighing your choices, Celeste Cisneros, FNP-BC will help you pick the right one for your anatomy, goals, and how often you want to come in.
Cost: Daxxify vs Botox in El Paso
At Solas Health & Wellness, Botox is $10 per unit and Daxxify is $9.50 per unit (at 20 or more units; $12/unit under 20). Pricing per unit may vary depending on the specific product and current promotions.
A typical forehead + glabella treatment uses 30–50 units, so a single Daxxify session usually runs about $475–$550 for a full upper-face dose (50–60 units) — in line with the commonly cited $375–$750 per 50-unit range. Here's how the annual cost math often works out:
Estimates based on Botox at $10/unit and Daxxify at $9.50/unit, 30–50 units per treatment. Your exact unit count depends on your treatment areas and facial anatomy. Get a personalized quote during your consultation.
Who Should Choose Daxxify?
Daxxify is an excellent choice if you:
- Notice Botox wearing off before 3 months (fast metabolizers)
- Have a busy schedule and don't want quarterly clinic visits
- Travel frequently and can't always make it back in time for touch-ups
- Want the convenience of just 1–2 appointments per year
- Prefer a product formulated without human albumin
- Are an experienced neurotoxin patient looking for longer-lasting results
Botox may be better if you:
- Are a first-time neurotoxin patient (the 3-month timeline allows easy adjustment)
- Want maximum flexibility to modify your look more frequently
- Prefer a product with 20+ years of real-world data
Both are excellent options. Your FNP-BC will review your goals and facial anatomy at your consultation to make a personalized recommendation.
"My Botox Stopped Working" — Is Daxxify the Answer?
One of the most common reasons people look into Daxxify is the feeling that their Botox stopped working or no longer lasts as long as it used to. Before switching, it helps to understand what's actually happening — because the right fix depends on the cause:
- Underdosing — the most common reason. If too few units were used for your muscle strength, results fade fast. The fix is often the correct dose, not a different product.
- Fast metabolism — some people break down neurotoxin more quickly and notice Botox fading at 8–10 weeks. This is where Daxxify's longer duration genuinely helps.
- Expectation mismatch — Botox is only designed to last 3–4 months. If you expected six, it can feel like it "stopped working" when it's actually behaving normally.
- True resistance (rare) — in uncommon cases, the body forms neutralizing antibodies to botulinum toxin type A. Because Daxxify is also a type A toxin, switching to it is not a guaranteed solution for genuine antibody-mediated resistance, and a provider evaluation is the right next step.
For the large majority of patients — fast metabolizers and people tired of quarterly touch-ups — Daxxify in El Paso is a meaningful upgrade because it's built to last 6–9 months. The honest answer: Daxxify solves the "wears off too fast" problem for most people, but it is not a cure-all for true immunologic resistance. An in-person assessment with Celeste Cisneros, FNP-BC will pin down the real cause and the right plan.
Side Effects & Safety
Both Botox and Daxxify have comparable, well-documented safety profiles. The most common side effects with either product include:
- Temporary bruising or redness at injection sites
- Mild headache (uncommon, typically resolves in 24 hours)
- Temporary eyelid or brow drooping (rare when injected by an experienced provider)
Daxxify's FDA approval was based on the SAKURA 1 and SAKURA 2 trials involving 2,858 patients, with a safety profile similar to existing neurotoxins. Headache was the most commonly reported adverse event in Daxxify trials at a slightly higher rate than Botox, though this was generally mild and self-resolving.
Both products are contraindicated during pregnancy and breastfeeding, and should not be used by patients with certain neuromuscular disorders. A qualified provider will review your medical history before treatment.
Getting Daxxify in El Paso, TX
Solas Health & Wellness is one of the only El Paso clinics offering Daxxify as an authorized Revance provider. We're located at 6633 N Mesa St, Suite 508, El Paso, TX 79912 — on the upper westside, easily accessible from all parts of the city.
Every neurotoxin treatment at Solas is performed by Celeste Cisneros, FNP-BC, a board-certified family nurse practitioner with over 10 years of clinical experience and specialized training in aesthetic medicine. You won't see a different injector at each visit — Celeste sees every patient personally.
What makes Solas unique in El Paso: we're the only clinic that combines aesthetic injectables (Botox, Daxxify, fillers) with functional medicine, IV therapy, TRT and hormone optimization, and medical weight loss — all under one board-certified provider. If your skin is reflecting how you feel on the inside, we can address both.
Ready to try Daxxify in El Paso?
Book a consultation with Celeste Cisneros, FNP-BC. We'll review your goals, compare Botox and Daxxify for your specific anatomy, and create a treatment plan that makes sense for your lifestyle.
Frequently Asked Questions
What is Daxxify and how is it different from Botox?
Daxxify (daxibotulinumtoxinA-lanm) is the newest FDA-approved neurotoxin, made by Revance Therapeutics. Unlike Botox, Daxxify uses a proprietary peptide instead of human albumin as a stabilizer. Both products work the same way — relaxing facial muscles to smooth wrinkles — but Daxxify lasts significantly longer: 6 months on average, sometimes up to 9 months, compared to Botox's 3–4 months.
How long does Daxxify last compared to Botox?
Botox typically lasts 3–4 months. Daxxify typically lasts 6 months, with clinical trials showing some patients maintaining results for up to 9 months. In Revance's FDA trials, 50% of patients maintained results at 6 months and 24% at 9 months — numbers Botox cannot match.
Is Daxxify safe?
Yes. Daxxify received FDA approval in September 2022 for glabellar lines (frown lines / '11s') after rigorous clinical trials involving over 2,800 patients. Its safety profile is comparable to Botox. Both are botulinum toxin type A products administered in small, controlled doses by licensed providers.
Does Daxxify cost more than Botox?
Per unit, Daxxify may be priced similarly or slightly higher than Botox depending on the provider. However, because Daxxify lasts twice as long, many patients save money overall — two Daxxify treatments per year instead of three or four Botox treatments per year. At Solas Health & Wellness in El Paso, Botox is $10 per unit and Daxxify is $9.50 per unit (at 20 or more units; $12/unit under 20). Your provider will estimate total units during your consultation.
Who is the best candidate for Daxxify vs Botox?
Daxxify is ideal for patients who: (1) are tired of returning every 3 months, (2) have busy schedules or travel frequently, (3) metabolize Botox quickly and notice it wears off before 3 months, or (4) simply want fewer clinic visits per year. Botox remains an excellent choice for first-time neurotoxin patients or those who prefer the flexibility of more frequent adjustments.
Can you get Daxxify in El Paso, TX?
Yes. Solas Health & Wellness at 6633 N Mesa St, Suite 508, El Paso, TX 79912 offers Daxxify administered by Celeste Cisneros, FNP-BC. Solas is an official Revance-authorized provider and one of the only El Paso clinics currently offering Daxxify.
Does Daxxify look different from Botox?
No. The aesthetic results — smoother forehead, softer frown lines, lifted brows — look identical to Botox. The only meaningful difference is duration. Both products produce natural-looking results when injected by an experienced provider.
Can Daxxify and Botox be combined in the same treatment?
In practice, providers use one product per session. Because Daxxify lasts longer, many patients transition fully to Daxxify to simplify their maintenance schedule. However, your provider can discuss the best approach for your anatomy and goals during a consultation.
What lasts longer than Botox?
Daxxify (daxibotulinumtoxinA-lanm) is currently the longest-lasting FDA-approved neurotoxin. Botox lasts about 3–4 months, while Daxxify lasts about 6 months on average — with some patients maintaining results up to 9 months. Other neurotoxins like Dysport and Xeomin last about the same as Botox; Daxxify is the standout for longevity.
Why did my Botox stop working, and will Daxxify help?
If your Botox seems to wear off early, the most common reasons are underdosing, a fast metabolism, or expecting it to last longer than Botox's normal 3–4 months — not true 'resistance,' which is rare. For most of these patients, Daxxify helps because it is formulated to last longer (6 months on average, up to 9). True immunologic resistance — where the body forms neutralizing antibodies to botulinum toxin type A — is uncommon, and because Daxxify is also a type A toxin, it is not a guaranteed fix for genuine antibody-mediated resistance. The right next step is an evaluation with your provider to confirm dosing and rule out other causes.
Can I switch from Botox to Daxxify?
Yes. You can switch at your next appointment — there is no required washout period. Many patients move to Daxxify once their Botox wears off, simply to get longer-lasting results and fewer visits per year. At Solas Health & Wellness in El Paso, Celeste Cisneros, FNP-BC reviews your history and goals and recommends the right dose for the switch.
What does Daxxify before and after look like?
Daxxify before-and-after results look the same as Botox: a smoother forehead, softened frown lines ('11s'), and a refreshed, natural appearance — not frozen. Full results appear about 2 weeks after treatment. You can see a real Solas patient's forehead before and after on our Daxxify El Paso page.
What's the difference between Botox and Dysport?
Botox (onabotulinumtoxinA) and Dysport (abobotulinumtoxinA) are both FDA-approved botulinum toxin type A injectables that relax muscles to smooth wrinkles, and both last about 3–4 months. The main differences: Dysport spreads slightly more, which some injectors prefer for larger areas like the forehead, and it's dosed differently — roughly 2.5–3 units of Dysport equal 1 unit of Botox. Daxxify, by contrast, lasts far longer (6–9 months). Solas offers Botox and Daxxify.
What lasts longer, Botox or Dysport?
Botox and Dysport last about the same — roughly 3–4 months each. Neither outlasts the other in any meaningful way. If your goal is longer-lasting results, Daxxify is the standout at 6–9 months, which is why many patients tired of frequent touch-ups switch to it.
How many units of Dysport equal Botox?
Dysport and Botox are not dosed 1:1. It generally takes about 2.5 to 3 units of Dysport to equal the effect of 1 unit of Botox. That's why Dysport's price per unit looks lower while the total cost of a treatment usually lands in a similar range. At Solas, Botox is dosed in standard Botox units at $10 per unit.
Daxxify vs Dysport: which lasts longer?
Daxxify lasts significantly longer than Dysport. Dysport lasts about 3–4 months, similar to Botox, while Daxxify lasts 6 months on average and up to 9 months for some patients. Daxxify is the longest-lasting FDA-approved neurotoxin available, thanks to its peptide-based formulation. Solas offers Daxxify in El Paso.