Daxxify lasts 6–9 months. Botox lasts 3–4 months. Both are FDA-approved botulinum toxin type A neurotoxins that smooth wrinkles. Daxxify uses a novel peptide stabilizer instead of human albumin, which is why it lasts longer. The results look identical — the only meaningful difference is how often you need to come back.
What Is Daxxify?
Daxxify (prabotulinumtoxinA-xvfs) is the newest FDA-approved neurotoxin, approved in September 2022 by Revance Therapeutics. It's the first truly new neurotoxin to enter the U.S. market in over a decade — and it's the only one that uses a proprietary stabilizing peptide instead of human serum albumin.
That one difference in formulation is why Daxxify lasts almost twice as long as Botox.
Botox (onabotulinumtoxinA) has been FDA-approved since 2002 and remains the most studied and trusted neurotoxin in the world. Over 8 million Botox treatments are performed annually in the U.S. alone.
How Long Does Each Last?
Most patients return every 3–4 months for maintenance. Some fast metabolizers may notice it fading at 10–12 weeks.
Clinical trials: 50% of patients maintained results at 6 months; 24% at 9 months. Most Daxxify patients come in just 1–2 times per year.
In Revance's FDA approval trials (the SAKURA 1 & 2 studies), Daxxify showed a median duration of 24 weeks — six months — for glabellar lines. Botox's clinical studies show a median duration of 16–18 weeks for the same area.
For patients who find Botox wearing off at 10 weeks or who simply hate scheduling quarterly appointments, Daxxify is a significant quality-of-life upgrade.
How They Work (And Why Daxxify Lasts Longer)
Both Botox and Daxxify are botulinum toxin type A neurotoxins. They work by temporarily blocking acetylcholine release at the neuromuscular junction — the signal that tells your facial muscles to contract. When the muscle can't contract, the overlying skin stays smooth.
The key difference is the stabilizing molecule:
- Botox uses human serum albumin to stabilize the toxin molecule.
- Daxxify uses a synthetic stabilizing peptide (the "xvfs" in its name). This peptide binds more tightly to the toxin, slowing degradation and extending how long it stays active in the tissue.
Daxxify is also the first neurotoxin formulated without human albumin, which matters to some patients who prefer a product that doesn't use human blood-derived components.
Daxxify vs Botox: Side-by-Side
| Feature | Botox® | Daxxify® |
|---|---|---|
| Generic name | OnabotulinumtoxinA | PrabotulinumtoxinA-xvfs |
| Manufacturer | AbbVie (Allergan) | Revance Therapeutics |
| FDA approved | 2002 | 2022 |
| Stabilizer | Human serum albumin | Synthetic peptide |
| Duration | 3–4 months | 6–9 months ✓ |
| Treatments/year | 3–4 sessions | 1–2 sessions ✓ |
| Approved areas | Forehead, glabella, crow's feet + more | Glabellar lines (FDA); used off-label for other areas |
| Results look | Natural, softened | Natural, softened (identical) |
| Onset | 3–5 days | 3–5 days |
| Human albumin | Yes | No ✓ |
| Clinical track record | 20+ years | 2022–present |
Cost: Daxxify vs Botox in El Paso
At Solas Health & Wellness, both Botox and Daxxify start at $9 per unit. Pricing per unit may vary depending on the specific product and current promotions.
A typical forehead + glabella treatment uses 30–50 units. Here's how the annual cost math often works out:
Estimates based on $9/unit, 30–50 units per treatment. Your exact unit count depends on your treatment areas and facial anatomy. Get a personalized quote during your consultation.
Who Should Choose Daxxify?
Daxxify is an excellent choice if you:
- Notice Botox wearing off before 3 months (fast metabolizers)
- Have a busy schedule and don't want quarterly clinic visits
- Travel frequently and can't always make it back in time for touch-ups
- Want the convenience of just 1–2 appointments per year
- Prefer a product formulated without human albumin
- Are an experienced neurotoxin patient looking for longer-lasting results
Botox may be better if you:
- Are a first-time neurotoxin patient (the 3-month timeline allows easy adjustment)
- Want maximum flexibility to modify your look more frequently
- Prefer a product with 20+ years of real-world data
Both are excellent options. Your FNP-BC will review your goals and facial anatomy at your consultation to make a personalized recommendation.
Side Effects & Safety
Both Botox and Daxxify have comparable, well-documented safety profiles. The most common side effects with either product include:
- Temporary bruising or redness at injection sites
- Mild headache (uncommon, typically resolves in 24 hours)
- Temporary eyelid or brow drooping (rare when injected by an experienced provider)
Daxxify's FDA approval was based on the SAKURA 1 and SAKURA 2 trials involving 2,858 patients, with a safety profile similar to existing neurotoxins. Headache was the most commonly reported adverse event in Daxxify trials at a slightly higher rate than Botox, though this was generally mild and self-resolving.
Both products are contraindicated during pregnancy and breastfeeding, and should not be used by patients with certain neuromuscular disorders. A qualified provider will review your medical history before treatment.
Getting Daxxify in El Paso, TX
Solas Health & Wellness is one of the only El Paso clinics offering Daxxify as an authorized Revance provider. We're located at 6633 N Mesa St, Suite 508, El Paso, TX 79912 — on the upper westside, easily accessible from all parts of the city.
Every neurotoxin treatment at Solas is performed by Celeste Cisneros, FNP-BC, a board-certified family nurse practitioner with over 10 years of clinical experience and specialized training in aesthetic medicine. You won't see a different injector at each visit — Celeste sees every patient personally.
What makes Solas unique in El Paso: we're the only clinic that combines aesthetic injectables (Botox, Daxxify, fillers) with functional medicine, IV therapy, TRT and hormone optimization, and medical weight loss — all under one board-certified provider. If your skin is reflecting how you feel on the inside, we can address both.
Ready to try Daxxify in El Paso?
Book a consultation with Celeste Cisneros, FNP-BC. We'll review your goals, compare Botox and Daxxify for your specific anatomy, and create a treatment plan that makes sense for your lifestyle.
Frequently Asked Questions
What is Daxxify and how is it different from Botox?
Daxxify (prabotulinumtoxinA-xvfs) is the newest FDA-approved neurotoxin, made by Revance Therapeutics. Unlike Botox, Daxxify uses a proprietary peptide instead of human albumin as a stabilizer. Both products work the same way — relaxing facial muscles to smooth wrinkles — but Daxxify lasts significantly longer: 6 months on average, sometimes up to 9 months, compared to Botox's 3–4 months.
How long does Daxxify last compared to Botox?
Botox typically lasts 3–4 months. Daxxify typically lasts 6 months, with clinical trials showing some patients maintaining results for up to 9 months. In Revance's FDA trials, 50% of patients maintained results at 6 months and 24% at 9 months — numbers Botox cannot match.
Is Daxxify safe?
Yes. Daxxify received FDA approval in September 2022 for glabellar lines (frown lines / '11s') after rigorous clinical trials involving over 2,800 patients. Its safety profile is comparable to Botox. Both are botulinum toxin type A products administered in small, controlled doses by licensed providers.
Does Daxxify cost more than Botox?
Per unit, Daxxify may be priced similarly or slightly higher than Botox depending on the provider. However, because Daxxify lasts twice as long, many patients save money overall — two Daxxify treatments per year instead of three or four Botox treatments per year. At Solas Health & Wellness in El Paso, both options start at $9/unit. Your provider will estimate total units during your consultation.
Who is the best candidate for Daxxify vs Botox?
Daxxify is ideal for patients who: (1) are tired of returning every 3 months, (2) have busy schedules or travel frequently, (3) metabolize Botox quickly and notice it wears off before 3 months, or (4) simply want fewer clinic visits per year. Botox remains an excellent choice for first-time neurotoxin patients or those who prefer the flexibility of more frequent adjustments.
Can you get Daxxify in El Paso, TX?
Yes. Solas Health & Wellness at 6633 N Mesa St, Suite 508, El Paso, TX 79912 offers Daxxify administered by Celeste Cisneros, FNP-BC. Solas is an official Revance-authorized provider and one of the only El Paso clinics currently offering Daxxify.
Does Daxxify look different from Botox?
No. The aesthetic results — smoother forehead, softer frown lines, lifted brows — look identical to Botox. The only meaningful difference is duration. Both products produce natural-looking results when injected by an experienced provider.
Can Daxxify and Botox be combined in the same treatment?
In practice, providers use one product per session. Because Daxxify lasts longer, many patients transition fully to Daxxify to simplify their maintenance schedule. However, your provider can discuss the best approach for your anatomy and goals during a consultation.